{"id":15,"date":"2025-06-26T17:17:37","date_gmt":"2025-06-26T08:17:37","guid":{"rendered":"https:\/\/nep-rhe.events.gunma-u.ac.jp\/0_cms\/?page_id=15"},"modified":"2026-04-13T17:57:53","modified_gmt":"2026-04-13T08:57:53","slug":"%e7%a0%94%e7%a9%b6%e7%b4%b9%e4%bb%8b","status":"publish","type":"page","link":"https:\/\/nep-rhe.events.gunma-u.ac.jp\/?page_id=15","title":{"rendered":"\u7814\u7a76\u7d39\u4ecb"},"content":{"rendered":"
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\u5f53\u6559\u5ba4\u3067\u306f\u86cb\u767d\u5c3f\u51fa\u73fe\u3084\u814e\u6a5f\u80fd\u60aa\u5316\u30fb\u81ea\u5df1\u514d\u75ab\u6027\u75be\u60a3\u767a\u75c7\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3064\u3044\u3066\u3001\u60a3\u8005\u3055\u3093\u306e\u691c\u4f53\uff08\u8840\u6db2\u3001\u5c3f\u3001\u814e\u7d44\u7e54\u306a\u3069\uff09\u3001\u907a\u4f1d\u5b50\u6539\u5909\u52d5\u7269\u3001\u57f9\u990a\u7d30\u80de\u3092\u4f7f\u7528\u3057\u3066\u591a\u9762\u7684\u306b\u7814\u7a76\u3057\u3066\u3044\u307e\u3059\u3002<\/h3>\n<\/div>\n
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\u57fa\u790e\u7814\u7a76<\/h2>\n

\u6559\u5ba4\u30b9\u30bf\u30c3\u30d5\u3068\u5927\u5b66\u9662\u751f\u304c\u30c1\u30fc\u30e0\u3092\u4f5c\u308a\u3001\u57fa\u790e\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<\/article>\n

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\u814e\u708e\u306e\u539f\u56e0\u89e3\u660e<\/h4>\n

\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u306e\u6a5f\u80fd\u7dad\u6301\u306b\u91cd\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bWT1\u306b\u95a2\u3059\u308b\u691c\u8a0e<\/h5>\n

\u6d5c\u8c37\u535a\u5b50\u75c5\u9662\u8b1b\u5e2b\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001TGF-\u03b2\u306b\u3088\u308a\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u306e\u6a5f\u80fd\u7dad\u6301\u306b\u91cd\u8981\u306a\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bWT1\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3053\u308c\u307e\u3067\u5831\u544a\uff08Nephrol Dial Transplant 2011<\/a>, Nephrology 2019<\/a>\uff09\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u7530\u90e8\u4e95\u5f6c\u53f2\u5148\u751f\u304c\u3053\u306e\u6a5f\u5e8f\u306b\u304a\u3051\u308bmicroRNA\u306e\u95a2\u4e0e\u3092\u691c\u8a0e\u3057\u3001\u7d50\u679c\u3092\u5831\u544a\u3057\u307e\u3057\u305f\uff08Am J Physiol Renal Physiol. 2023 Jul 1;325(1):F121-F133.<\/a>\uff09\u3002\u3055\u3089\u306b\u540c\u30b0\u30eb\u30fc\u30d7\u306e\u6700\u65b0\u306e\u7814\u7a76\u3067\u306f\u3001\u5225\u306e\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bATOH8\u306b\u7740\u76ee\u3057\u3001\u7cf8\u7403\u4f53\u4e0a\u76ae\u7d30\u80de\u306b\u304a\u3051\u308b\u305d\u306e\u4fdd\u8b77\u7684\u306a\u5f79\u5272\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\uff08Am J Physiol Renal Physiol. 2026<\/a>\uff09\u3002<\/p>\n

\u6a39\u72b6\u7d30\u80de\u7279\u7570\u7684\u306b\u7d30\u7d30\u80de\u8cea\u578b\u30c1\u30ed\u30b7\u30f3\u8131\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3067\u3042\u308bSHP-1\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9\u3092\u5229\u7528\u3057\u305f\u691c\u8a0e<\/h5>\n

\u6e21\u8fba\u5149\u6cbb\u5148\u751f\u306b\u3088\u308a\u3001\u30d5\u30ed\u30fc\u30b5\u30a4\u30c8\u30e1\u30c8\u30ea\u30fc\u6cd5\u3092\u5229\u7528\u3057\u3066\u3001\u814e\u5358\u6838\u98df\u7d30\u80de\u3068\u547c\u3070\u308c\u308b\u814e\u306b\u5e38\u5728\u3059\u308b\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3084\u6a39\u72b6\u7d30\u80de\u304b\u3089\u306a\u308b\u8907\u6570\u306e\u4e9c\u7fa4\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3059\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3057\u3066\u3001Biochem Biophys Rep.\u306b2020\u5e74\u306b\u767a\u8868\u3057\u307e\u3057\u305f\uff08Biochem Biophys Rep. 2020 Mar 4;22:100741.<\/a>\uff09\u3002
\n\u73fe\u5728\u3001\u3053\u306e\u89e3\u6790\u65b9\u6cd5\u3092\u7528\u3044\u3066\u3001\u6a39\u72b6\u7d30\u80de\u7279\u7570\u7684SHP-1\u6b20\u640d\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u751f\u3058\u308b\u5c3f\u7d30\u7ba1\u9593\u8cea\u969c\u5bb3\u6a5f\u5e8f\u306e\u89e3\u660e\u3092\u884c\u3044\u3001\u8ad6\u6587\u6295\u7a3f\u6e96\u5099\u4e2d\u3067\u3059\u3002<\/p>\n

\u8acf\u8a2a\u7d62\u4e5f\u52a9\u6559\uff08\u75c5\u9662\uff09\u3068\u4eca\u4e95\u967d\u4e00\u5148\u751f\u306f\u30de\u30a6\u30b9\u814e\u7d44\u7e54\u304b\u3089\u5c3f\u7d30\u7ba1\u9593\u8cea\u7dda\u7dad\u82bd\u7d30\u80de\u3092\u6e21\u8fba\u5148\u751f\u304c\u958b\u767a\u3057\u305f\u624b\u6cd5\u3092\u7528\u3044\u3066\u5206\u753b\u3057\u3001\u814e\u7dda\u7dad\u5316\u6a5f\u5e8f\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u3092\u30c6\u30fc\u30de\u306b\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u81ea\u5df1\u514d\u75ab\u6027\u75be\u60a3\u306e\u6a5f\u5e8f\u306e\u89e3\u660e<\/h4>\n

\u6728\u4e0b\u96c5\u4eba\u52a9\u6559\uff08\u75c5\u9662\uff09\u306f\u3001\u6a39\u72b6\u7d30\u80de\u7279\u7570\u7684SHP-1\u6b20\u640d\u30de\u30a6\u30b9\u304c\u6d99\u817a\u708e\u3001\u553e\u6db2\u817a\u3092\u81ea\u7136\u767a\u75c7\u3057\u30b7\u30a7\u30fc\u30b0\u30ec\u30f3\u75c7\u5019\u7fa4\u306e\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u3082\u306a\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u30022020\u5e74\u306e\u6b27\u5dde\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\u3067\u767a\u8868\u3057\u3001\u73fe\u5728\u8ad6\u6587\u6295\u7a3f\u6e96\u5099\u4e2d\u3067\u3059\u3002<\/p>\n

\u672c\u30de\u30a6\u30b9\u306f\u8010\u7cd6\u80fd\u969c\u5bb3\u304c\u751f\u3058\u308b\u3053\u3068\u3082\u5224\u660e\u3057\u3066\u304a\u308a\u3001\u5927\u5b66\u9662\u751f\u306eShrestha Shreya\u3055\u3093\u304c2019\u5e74\u306e\u65e5\u672c\u514d\u75ab\u5b66\u4f1a\u3067\u767a\u8868\u3057\u3001\u73fe\u5728\u8ad6\u6587\u6295\u7a3f\u4e2d\u3067\u3059\u3002<\/p>\n<\/article>\n

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\u81e8\u5e8a\u7814\u7a76<\/h2>\n

\u5168\u56fd\u306e\u533b\u7642\u6a5f\u95a2\u30fb\u65bd\u8a2d\u3068\u5171\u540c\u3001\u3042\u308b\u3044\u306f\u5f53\u79d1\u3067\u306e\u8a3a\u7642\u6210\u7e3e\u3092\u5143\u306b\u814e\u81d3\u30fb\u30ea\u30a6\u30de\u30c1\u6027\u75be\u60a3\u306e\u81e8\u5e8a\u7814\u7a76\u3092\u7d99\u7d9a\u3057\u3066\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u306b\u95a2\u3057\u3066\u306f\u814e\u75be\u60a3\u30fb\u30ea\u30a6\u30de\u30c1\u6027\u75be\u60a3\u4e21\u8005\u306e\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u3067\u3042\u308b\u5f53\u79d1\u306e\u7279\u8272\u3092\u5341\u4e8c\u5206\u306b\u751f\u304b\u3057\u3001\u4e16\u754c\u7684\u306b\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u7814\u7a76\u304c\u9032\u884c\u4e2d\u3067\u3059\u3002MMF\u3068TAC\u3092\u4f75\u7528\u3057\u305f\u30de\u30eb\u30c1\u30bf\u30fc\u30b2\u30c3\u30c8\u7642\u6cd5\u306e\u5831\u544a\uff08Mod Rheumatol. 2014 Jul;24(4):618-25.<\/a>\uff09\u306b\u95a2\u3057\u3066\u306f\u30012019\u5e74\u306e\u30e8\u30fc\u30ed\u30c3\u30d1\u30ea\u30a6\u30de\u30c1\u5b66\u4f1a\u3067\u306e\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u3082\u5f53\u79d1\u306e\u6cbb\u7642\u6210\u7e3e\u304c\u5f15\u7528\u3055\u308c\u3066\u3044\u307e\u3059 \uff08Ann Rheum Dis 78 : 736-745, 2019.<\/a>\uff09 \u3002\u73fe\u5728\u4eca\u4e95\u967d\u4e00\u5148\u751f\u306b\u3088\u308a\u30de\u30eb\u30c1\u30bf\u30fc\u30b2\u30c3\u30c8\u7642\u6cd5\u306e\u9577\u671f\u4e88\u5f8c\u304a\u3088\u3073\u6cbb\u7642\u62b5\u6297\u6027\u56e0\u5b50\u306b\u95a2\u3057\u89e3\u6790\u3092\u9032\u3081\u3066\u304a\u308a\u3001\u6295\u7a3f\u6e96\u5099\u4e2d\u3067\u3059\u3002\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u306b\u5bfe\u3059\u308b\u30d9\u30ea\u30e0\u30de\u30d6\u306e\u7b2c3\u76f8\u8a66\u9a13\u3067\u3042\u308bBLISS-LN\u306e\u30b5\u30d6\u89e3\u6790\u306b\u95a2\u3057\u3066\u3082\u5ee3\u6751\u6559\u6388\u304c\u5171\u540c\u8457\u8005\u3068\u3057\u3066\u95a2\u308f\u308a\u307e\u3057\u305f\uff08Nephrol Dial Transplant. 2023 Nov 30;38(12):2733-2742. <\/a>\uff09\u3002<\/p>\n

\u65e5\u672c\u814e\u81d3\u5b66\u4f1a\u304a\u3088\u3073\u539a\u751f\u52b4\u50cd\u7701\u306e\u30ec\u30b8\u30b9\u30c8\u30ea\u3092\u4f7f\u7528\u3057\u3001\u56fd\u5185\u306e\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u60a3\u8005\u306e\u89e3\u6790\u3092\u884c\u3044\u767a\u8868\u3057\u3066\u3044\u307e\u3059\uff08Clin Exp Nephrol. 2025 Oct;29(10):1363-1372.<\/a>, Nephrology (Carlton). 2017 Nov;22(11):885-891., Clin Exp Nephrol. 2022 Sep;26(9):898-908.<\/a>)\u3002<\/p>\n

\u8acf\u8a2a\u7d62\u4e5f\u52a9\u6559\uff08\u75c5\u9662\uff09\u306b\u3088\u308a\u30eb\u30fc\u30d7\u30b9\u814e\u708e\u306e\u65b0\u898f\u5c3f\u4e2d\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u691c\u8a0e\u3092\u884c\u3063\u3066\u304a\u308a\u3001\u6210\u679c\u306e\u4e00\u90e8\u3092\u540d\u53e4\u5c4b\u5927\u5b66\u3068\u306e\u5171\u540c\u7814\u7a76\u3068\u3057\u3066\u767a\u8868\u3057\u3066\u3044\u307e\u3059\uff08Kidney Int. 2019 Mar;95(3):680-692.<\/a> \uff09\u3002<\/p>\n

\u5927\u77f3\u88d5\u5b50\u5148\u751f\uff08\u73fe\u5927\u962a\u5927\u5b66\u7279\u4efb\u52a9\u6559\uff09\u304c\u5f53\u79d1\u306eSLE\u60a3\u8005\u7d04100\u4ef6\u306e\u598a\u5a20\u8ee2\u5e30\u3092\u307e\u3068\u3081\u307e\u3057\u305f\uff08Clin Exp Nephrol. 2021 Aug;25(8):835-843.<\/a> \uff09\u3002<\/p>\n

\u7530\u90e8\u4e95\u5f6c\u53f2\u5148\u751f\u304c\u5f53\u79d1\u3067\u306eANCA\u95a2\u9023\u8840\u7ba1\u708e\uff08AAV\uff09\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u69cb\u7bc9\u3059\u308b\u904e\u7a0b\u3067\u3001PR3\u967d\u6027ANCA\u95a2\u9023\u8840\u7ba1\u708e\u304a\u3088\u3073\u4e2d\u8033\u708e\uff08OMAAV\uff09\u306e\u60a3\u8005\u306e\u4e88\u5f8c\u4e88\u6e2c\u56e0\u5b50\u307e\u3068\u3081\u3001\u5831\u544a\u3057\u307e\u3057\u305f\uff08Clin Rheumatol. 2026 Jan;45(1):365-373.<\/a>, <\/span>Mod Rheumatol . 2022 Aug 20;32(5):923-929.<\/a>\uff09\u3002<\/p>\n

\u305d\u306e\u4ed6\u3001ANCA\u95a2\u9023\u8840\u7ba1\u708e\u306b\u95a2\u3057\u3066\u306f\u30ea\u30c4\u30ad\u30b7\u30de\u30d6\u306b\u3088\u308a\u30b9\u30c6\u30ed\u30a4\u30c9\u4f7f\u7528\u91cf\u306e\u6e1b\u91cf\u3092\u56f3\u3063\u305fLoVAS\u8a66\u9a13\u3092\u4ed6\u65bd\u8a2d\u5171\u540c\u3067\u884c\u3044\u3001\u6210\u679c\u3092\u767a\u8868\u3057\u3066\u3044\u307e\u3059\uff08JAMA. 2021 Jun 1;325(21):2178-2187.)(Ann Rheum Dis. 2024 Jan 2;83(1):96-102.<\/a>\uff09\u3002<\/p>\n<\/article>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

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